Journal article
Childhood wheeze phenotypes show less than expected growth in FEV 1 across adolescence
CJ Lodge, AJ Lowe, KJ Allen, S Zaloumis, LC Gurrin, MC Matheson, C Axelrad, L Welsh, CM Bennett, J Hopper, PS Thomas, DJ Hill, CS Hosking, C Svanes, MJ Abramson, SC Dharmage
American Journal of Respiratory and Critical Care Medicine | Published : 2014
Abstract
Rationale: Better characterization of childhood wheeze phenotypes using newer statistical methods provides a basis for addressing the heterogeneity of childhood asthma. Outcomes of these phenotypes beyond childhood are unknown. Objectives: To determine if adolescent respiratory symptoms, lung function, and changes in lung function over adolescence differ by childhood wheeze phenotypes defined through latent class analysis. Methods: A prospective birth cohort (Melbourne Atopy Cohort Study) followed 620 high allergy-risk children, recording respiratory symptoms and spirometry at 12 and 18 years. Regression analyses identified relationships between wheeze phenotypes (never/infrequent, early tra..
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Funding Acknowledgements
This work was supported by the Sidney Myer Health Fund (C.J.L.), by the National Health and Medical Research Council of Australia (NHMRC) (C.J.L., A.J.L., L.C.G., M.C.M., and S.C.D.), and by the Charles and Sylvia Viertel Charitable Foundation (K.J.A).