Journal article
The effect of known cardiovascular risk factors on carotid-femoral pulse wave velocity in school-aged children: A population based twin study
K McCloskey, C Sun, A Pezic, J Cochrane, R Morley, P Vuillermin, D Burgner, T Dwyer, AL Ponsonby
Journal of Developmental Origins of Health and Disease | CAMBRIDGE UNIV PRESS | Published : 2014
Abstract
Childhood cardiovascular risk factors affect vascular function long before overt cardiovascular disease. Twin studies provide a unique opportunity to examine the influence of shared genetic and environmental influences on childhood cardiovascular function. We examined the relationship between birth parameters, markers of adiposity, insulin resistance, lipid profile and blood pressure and carotid-femoral pulse wave velocity (PWV), a validated non-invasive measure of arterial stiffness in a healthy cohort of school-aged twin children. PWV was performed on a population-based birth cohort of 147 twin pairs aged 7-11 years. Fasting blood samples, blood pressure and adiposity measures were collect..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
The Tasmanian Infant Health Survey was supported by the US National Institutes of Health Grant 001 HD28979-01A1, Tasmanian State Government, Australian Rotary Health Research Fund, National Health and Medical Research Council of Australia, National Sudden Infant Death Syndrome Council of Australia, Sudden Infant Death Research Foundation of Victoria and other constituent organizations, Community Organizations' Support Program of the Department of Human Services and Health, Zonta International, Wyeth Pharmaceuticals and Tasmanian Sanatoria After-Care Association. K. M. has a Sydney Myer research grant. A.-L. P holds a senior research fellowship with the National Health and Medical Research Council.