Journal article
Characterization of G2P[4] rotavirus strains associated with increased detection in Australian states using the RotaTeq® vaccine during the 2010-2011 surveillance period
CM Donato, ZA Zhang, NC Donker, CD Kirkwood
Infection Genetics and Evolution | Published : 2014
Abstract
The introduction of rotavirus vaccines Rotarix® and RotaTeq® into the Australian National Immunisation Program in July 2007 has resulted in a dramatic decrease in the burden of rotavirus disease. G2P[4] strains became the dominant genotype Australia-wide during the 2010-2011 surveillance period and for the first time since vaccine introduction, a higher proportion were isolated in jurisdictions using RotaTeq® vaccine compared to locations using Rotarix®. Phylogenetic analysis of the VP7 gene of 32 G2P[4] strains identified six genetic clusters, these distinct clusters were also observed in the VP4 gene for a subset of 12 strains. The whole genome was determined for a representative strain of..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
C.D. Kirkwood is director of Australian Rotavirus Surveillance Program, which is supported by research grants from vaccine manufacturers CSL, GSK and Merck. This work was supported by grants from the National Health and Medical Research Council of Australia [1031473]; Australian Commonwealth Department of Health; GSK Biologicals (Melbourne, Australia); and CSL (Melbourne, Australia). C.D. Kirkwood is supported by a Career Development Award from the National Health and Medical Research Council of Australia [607347]. This study was supported by the Victorian Government's Operational Infrastructure Support Program.