Journal article
Aspirin and clonidine in non-cardiac surgery: Acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial
AX Garg, A Kurz, DI Sessler, M Cuerden, A Robinson, M Mrkobrada, C Parikh, R Mizera, PM Jones, M Tiboni, RG Rodriguez, E Popova, MFR Gomez, CS Meyhoff, T Vanhelder, MTV Chan, D Torres, J Parlow, M De Nadal Clanchet, M Amir Show all
BMJ Open | Published : 2014
Abstract
Introduction: Perioperative Ischaemic Evaluation-2 (POISE-2) is an international 2x2 factorial randomised controlled trial of low-dose aspirin versus placebo and low-dose clonidine versus placebo in patients who undergo non-cardiac surgery. Perioperative aspirin (and possibly clonidine) may reduce the risk of postoperative acute kidney injury (AKI). Methods and analysis: After receipt of grant funding, serial postoperative serum creatinine measurements began to be recorded in consecutive patients enrolled at substudy participating centres. With respect to the study schedule, the last of over 6500 substudy patients from 82 centres in 21 countries were randomised in December 2013. The authors ..
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Awarded by National Institutes of Health
Funding Acknowledgements
The POISE-2 trial and the AKI substudy are funded by two grants from the Canadian Institutes of Health Research (application number of the AKI substudy: 259720). General support for POISE-2 was also provided by the Australian National Health and Medical Research Council and the Spanish Ministry of Health and Social Policy. Boehringer Ingelheim provided the clonidine study drug and some funding, and Bayer Schering Pharma provided the aspirin study drug. The sponsors of POISE-2 and the AKI substudy had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of this protocol paper; and decision to submit this protocol manuscript for publication.