Journal article

Prediction of the hazard of foetal malformation in pregnant women with epilepsy

FJE Vajda, TJ O'Brien, J Graham, CM Lander, MJ Eadie



The data collected in the Australian Register of antiepileptic drugs in pregnancy have been studied in the hope of defining simple items of information that could be recorded at initial interview of pregnant women with epilepsy, and which might allow estimation of the risk of the pregnancy resulting in a malformed foetus. Analysis of the data showed that dose of valproate, but not intake of other commonly used antiepileptic drugs, in the current pregnancy, and a past history of a pregnancy involving a malformed foetus, statistically significantly increased the malformation hazard in the current pregnancy, and that continuing alcohol intake might decrease it. Plotting the hazard against valpr..

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Funding Acknowledgements

We wish to thank medical and non-medical colleagues, both for referring WWE and for making such women increasing awareness of the Register. We are grateful to the Scientific Advisory Board and the Ethical Research Committees of St. Vincent's Hospital, Monash Medical Centre, the Royal Melbourne Hospital and other institutions for their ethics oversight of the Register. The continuing financial support of the Epilepsy Society of Australia, The Victorian Epilepsy Foundation, Epilepsy Australia and a number of pharmaceutical companies, including Sanofi-Aventis, UCB Pharma, Janssen-Cilag, Novartis, Sci-Gen and Pfizer, and previously from Glaxo, has helped maintain the Register.