Journal article
Interplay of Intrinsic and Synaptic Conductances in the Generation of High-Frequency Oscillations in Interneuronal Networks with Irregular Spiking
F Baroni, AN Burkitt, DB Grayden
Plos Computational Biology | Published : 2014
Abstract
High-frequency oscillations (above 30 Hz) have been observed in sensory and higher-order brain areas, and are believed to constitute a general hallmark of functional neuronal activation. Fast inhibition in interneuronal networks has been suggested as a general mechanism for the generation of high-frequency oscillations. Certain classes of interneurons exhibit subthreshold oscillations, but the effect of this intrinsic neuronal property on the population rhythm is not completely understood. We study the influence of intrinsic damped subthreshold oscillations in the emergence of collective high-frequency oscillations, and elucidate the dynamical mechanisms that underlie this phenomenon. We sim..
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Funding Acknowledgements
This work was supported by ARC Discovery Grant DP1096699 and by Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0003 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government. The Bionics Institute acknowledges the support it receives from the Victorian State Government through the Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.