Journal article
In vivo IFN-γ secretion by NK cells in response to Salmonella typhimurium requires NLRC4 inflammasomes
A Kupz, R Curtiss, S Bedoui, RA Strugnell
Plos One | Published : 2014
Abstract
Natural killer (NK) cells are a critical part of the innate immune defense against viral infections and for the control of tumors. Much less is known about how NK cells contribute to anti-bacterial immunity. NK cell-produced interferon gamma (IFN-γ) contributes to the control of early exponential replication of bacterial pathogens, however the regulation of these events remains poorly resolved. Using a mouse model of invasive Salmonellosis, here we report that the activation of the intracellular danger sensor NLRC4 by Salmonella -derived flagellin within CD11c+ cells regulates early IFN-γ secretion by NK cells through the provision of interleukin 18 (IL-18), independently of Toll-like recept..
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Grants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NH&MRC) https://www.nhmrc.gov.au/ [Program Grant: Fighting Infection, exploiting host-pathogen interactions APP606788 to R.A.S., Career Development Award APP628464 to S. B., CJ Martin Biomedical Early Career Fellowship APP1052764 to A.K.]; and IH R01AI60557 and Bill and Melinda Gates Foundation Grant no. 37863 to R. C. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.