Journal article
Myelin paucity of the superior cerebellar peduncle in individuals with Friedreich ataxia: An MRI magnetization transfer imaging study
LA Corben, SR Kashuk, H Akhlaghi, S Jamadar, MB Delatycki, J Fielding, B Johnson, N Georgiou-Karistianis, GF Egan
Journal of the Neurological Sciences | ELSEVIER SCIENCE BV | Published : 2014
Abstract
The dentate nucleus (DN) is the major relay station for neural connection between the cerebellum and cerebrum via the thalamus, and is a significant component of the neuropathological profile of Friedreich ataxia (FRDA). We have previously shown that the size of the superior cerebellar peduncle (SCP), which links the DN to cortical and subcortical structures via the thalamus, is significantly reduced in individuals with FRDA compared to control participants. This study used magnetization transfer imaging (MTI) to examine and contrast the integrity of white matter (WM) in the SCP and the corpus callosum (CC) (control region) in ten individuals with FRDA and ten controls. Individuals with FRDA..
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Funding Acknowledgements
The authors thank the participants for their involvement in this study and the staff at Monash Biomedical Imaging, Monash University, Victoria. Funding for this study was from a Monash Biomedical Imaging Psychology Department Grant. LAC is an early career fellow, MBD is a practitioner fellow, GE is a research fellow-all of the National Health and Medical Research Council. SRK is the recipient of a Victoria University Postgraduate Research Scholarship. The authors also wish to acknowledge the support of the Friedreich Ataxia Research Alliance (USA) and the Friedreich Ataxia Research Association (Australasia).