Journal article

Lennox-Gastaut syndrome and phenotype: Secondary network epilepsies

John S Archer, Aaron EL Warren, Monique R Stagnitti, Richard AJ Masterton, David F Abbott, Graeme D Jackson

EPILEPSIA | WILEY | Published : 2014

Abstract

OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a severe epilepsy phenotype with characteristic electroclinical features despite diverse etiologies. We previously found common cerebral networks involved during slow spike-and-wave (SSW) and generalized paroxysmal fast activity (PFA), characteristic interictal discharges. Some patients have a Lennox-Gastaut-like phenotype and cortical lesions. We wished to explore the interaction between cerebral networks and lesions in this group. METHODS: 3 Tesla electroencephalography-functional magnetic resonance imaging (EEG-fMRI) on six subjects with Lennox-Gastaut phenotype and a structural lesion. Timings of SSW and PFA events were used in an event-related..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

We thank the patients and their families for participating in our research; Shawna Farquharson for radiography; and Dr Danny Flanagan for performing and reviewing EEG records. This study was supported by the National Health and Medical Research Council of Australia (Project grant no. 628725 program grant 628957, practitioner fellowship (GDJ) 527800) and the Operational Infrastructure Support Program of the State Government of Victoria, Australia.