Journal article
Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children
FJ Cameron, SE Scratch, C Nadebaum, EA Northam, I Koves, J Jennings, K Finney, JJ Neil, RM Wellard, M Mackay, TE Inder
Diabetes Care | Published : 2014
DOI: 10.2337/dc13-1904
Abstract
OBJECTIVE To investigate the impact of new-onset diabetic ketoacidosis (DKA) during childhood on brain morphology and function. RESEARCH DESIGN AND METHODS Patients aged 6-18 years with and without DKA at diagnosis were studied at four time points: < 48 h, 5 days, 28 days, and 6 months postdiagnosis. Patients underwent magnetic resonance imaging (MRI) and spectroscopy with cognitive assessment at each time point. Relationships between clinical characteristics at presentation and MRI and neurologic outcomes were examined using multiple linear regression, repeated-measures, and ANCOVA analyses. RESULTS Thirty-six DKA and 59 non-DKA patients were recruited between 2004 and 2009. With DKA, cereb..
View full abstractGrants
Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Acknowledgements
This study was funded by JDRF and the Australian National Health and Medical Research Council (project grant 334354). T.E.I. is supported by the Doris Duke Charitable Foundation, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant P30-HD-062171), and the Washington University Intellectual and Developmental Disability Research Center.