Journal article
Incidence of cerebral microbleeds in preclinical Alzheimer disease
PA Yates, PM Desmond, PM Phal, C Steward, C Szoeke, O Salvado, KA Ellis, RN Martins, CL Masters, D Ames, VL Villemagne, CC Rowe
Neurology | Published : 2014
Abstract
Objective: We sought to determine the incidence and associations of lobar microbleeds (LMBs) in a longitudinal cohort with 11C-Pittsburgh compound B (PiB) PET imaging. Methods: One hundred seventy-four participants from the observational Australian Imaging, Biomarkers and Lifestyle Study of Ageing (97 with normal cognition [NC], 37 with mild cognitive impairment [MCI], and 40 with Alzheimer disease [AD] dementia) were assessed at 3 time points over 3 years with 3-tesla susceptibility-weighted MRI and 11C-PiB PET. MRIs were inspected for microbleeds, siderosis, infarction, and white matter hyperintensity severity, blind to clinical and PiB findings. Neocortical PiB standardized uptake value r..
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Funding Acknowledgements
Funding for the study was provided in part by the study partners (Australian Commonwealth Scientific Industrial and Research Organization, Edith Cowan University, Mental Health Research Institute, Alzheimer's Australia, National Ageing Research Institute, Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gardner Hospital). The study also received support from the National Health and Medical Research Council and the Dementia Collaborative Research Centres program, as well as ongoing funding from the Science and Industry Endowment Fund.