Journal article
Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1
L Morenos, Z Chatterton, JL Ng, MS Halemba, M Parkinson-Bates, F Mechinaud, N Elwood, R Saffery, NC Wong
Molecular Cancer | Published : 2014
Abstract
Background: Acute Myeloid Leukaemia (AML) is a highly heterogeneous disease. Studies in adult AML have identified epigenetic changes, specifically DNA methylation, associated with leukaemia subtype, age of onset and patient survival which highlights this heterogeneity. However, only limited DNA methylation studies have elucidated any associations in paediatric AML.Methods: We interrogated DNA methylation on a cohort of paediatric AML FAB subtype M5 patients using the Illumina HumanMethylation450 (HM450) BeadChip, identifying a number of target genes with p 0.4 between leukaemic and matched remission (n = 20 primary leukaemic, n = 13 matched remission). Amongst those genes identified, we inte..
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Awarded by Victorian Cancer Agency
Funding Acknowledgements
This work was supported by the Victorian Cancer Agency Grant and National Health & Medical Research Council (NHMRC), Australia [Project Grant number 607306] (N.W.); MCRI is supported by the Victorian Government's Operational Infrastructure Support Program; the National Health & Medical Research Council Dora Lush Postgraduate Scholarship to L. M.; NHMRC Senior Research Fellowship to R. S.; The Leukaemia Foundation of Australia Phillip Desbrow Postdoctoral Fellowship (N.W.) and Project Grant in Aid(N.W. & R. S.); N.W. was also supported by My Room and the Children's Cancer Centre Foundation.