Journal article
Comparative analysis of outcome measures used in examining neurodevelopmental effects of early childhood anesthesia exposure
CH Ing, CJ Dimaggio, E Malacova, AJ Whitehouse, MK Hegarty, T Feng, JE Brady, BS Von Ungern-Sternberg, AJ Davidson, MM Wall, AJJ Wood, G Li, LS Sun
Anesthesiology | Published : 2014
Abstract
INTRODUCTION:: Immature animals exposed to anesthesia display apoptotic neurodegeneration and neurobehavioral deficits. The safety of anesthetic agents in children has been evaluated using a variety of neurodevelopmental outcome measures with varied results. METHODS:: The authors used data from the Western Australian Pregnancy Cohort (Raine) Study to examine the association between exposure to anesthesia in children younger than 3 yr of age and three types of outcomes at age of 10 yr: neuropsychological testing, International Classification of Diseases, 9th Revision, Clinical Modification-coded clinical disorders, and academic achievement. The authors' primary analysis was restricted to chil..
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Funding Acknowledgements
This work was supported in part by a grant from SmartTots (San Francisco, California). The Western Australian Pregnancy Cohort Study is funded by project and program grants from the National Health and Medical Research Council of Australia (Canberra, Australia). Core management funding is provided by the Raine Medical Research Foundation, the Telethon Institute for Child Health Research, the University of Western Australia (UWA), the UWA Faculty of Medicine, Dentistry, and Health Sciences, the Women and Infants Research Foundation, and Curtin University. All institutions providing core management funding reside in Perth, Australia. Dr. von Ungern-Sternberg is partly funded by the Princess Margaret Hospital Foundation and Woolworths Australia (Perth, Australia).