Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats

HCS Abeysinghe; L Bokhari; GJ Dusting; CL Roulston

Journal article

Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats

HCS Abeysinghe, L Bokhari, GJ Dusting, CL Roulston

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014

DOI: 10.1371/journal.pone.0097007

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Abstract

The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as inflammation and scar formation and cellular responses within the subventricular zone (SVZ) following transient focal ischemia in rats (n = 34). Endothelin-1-induced stroke resulted in neurological deficits detected between 1 and 7 days (P<0.001), but significant recovery was observed beyond this time. MCID image analysis revealed varying degrees of damage in the ipsilateral cortex and striatum with infarct volumes ranging from 0.76-77 mm3 after 14 days, where larger infarct v..

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University of Melbourne Researchers

Gregory Dusting Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported in part by grants from the National Heart Foundation Australia (NHF G07M3237, http://www.heartfoundation.org.au); The Bethlehem Griffiths Foundation (http://www.bethlehemgrf.com.au/); and the National Health and Medical Research Council Australia for project grant (NHMRC project grant 628767, http://www.nhmrc.gov.au/), and fellowship to Professor Dusting (No. 1003113). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.