Journal article
A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism
YC Liu, Z Chen, MA Neller, JJ Miles, AW Purcell, J McCluskey, SR Burrows, J Rossjohn, S Gras
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2014
Open access
Abstract
Mutations within T cell epitopes represent a common mechanism of viral escape from the host protective immune response.Thediverse T cell repertoire and the extensive human leukocyte antigen (HLA) polymorphism across populations is the evolutionary response to viral mutation. However, the molecular basis underpinning the interplay between HLA polymorphism, the Tcell repertoire, and viral escape is unclear. Here we investigate the T cell response to a HLA-B*35:01-and HLA-B*35:08-restricted 407HPVGEADYFEY417 epitope from Epstein-Barr virus and naturally occurring variants at positions 4 and 5 thereof. Each viral variant differently impacted on the epitope's flexibility and conformation when bou..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
[ "This work was supported by the Australian Research Council and National Health and Medical Research Council of Australia Grants APP1067374 and APP1021620.", "Supported by a National Health and Medical Research Council of Australia Career Development Fellowship.", "Supported by a National Health and Medical Research Council of Australia Senior Research Fellowship.", "Supported by an Australia Fellowship from the National Health and Medical Research Council. To whom correspondence may be addressed: Dept. of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Vic 3800 Australia. Tel.: 613-99029236; Fax: 613-9902500; E-mail: jamie.rossjohn@monash.edu." ]