Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia
Grace J Liu, Luisa Cimmino, Julian G Jude, Yifang Hu, Matthew T Witkowski, Mark D McKenzie, Mutlu Kartal-Kaess, Sarah A Best, Laura Tuohey, Yang Liao, Wei Shi, Charles G Mullighan, Michael A Farrar, Stephen L Nutt, Gordon K Smyth, Johannes Zuber, Ross A Dickins
Genes & Development | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2014
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by National Institutes of Health USA
Awarded by Austrian Science Fund
We thank M. Salzone, M. Dayton, P. Kennedy, K. Stoev, C. Smith, L. Wilkins, M. Howell, T. Carle, E. Lanera, S. Brown, and other Walter and Eliza Hall Institute Bioservices staff; W. Alexander for embryonic stem cell resources; E. Viney and J. Sarkis at the Australian Phenomics Network Transgenic RNAi service; M. Everest and M. Tinning at the Australian Genome Research Facility; and R. Lane, T. Willson, J. Corbin, and C. Hyland for technical expertise. We thank S. Lowe for vectors, D. Largaespada for Vav-tTA transgenic mice, and M. Jaritz and M. Busslinger for Pax5 ChIP-seq data. We thank S. Chappaz, D. Tarlinton, D. Hilton, M. Busslinger, and S. Lowe for advice and discussions. This work was supported by the National Health and Medical Research Council (NHMRC) of Australia project grants 575535, 1024599, and 1023454; Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme (MISS); an Australian Research Council Future Fellowship (to S.L.N.); an NHMRC Research Fellowship (to G.K.S.); National Institutes of Health USA grants R01 CA151845 and CA154998 (to M.A.F.); Austrian Science Fund grant F4710-B20 (to J.Z.); Boehringer Ingelheim Institutional funding (to J.Z. and J.G.J.); the Leukaemia Foundation of Australia (G.J.L., M.T.W., and M.D.M.); a Sylvia and Charles Viertel Charitable Foundation Fellowship (to R.A.D.); Victorian State Government Operational Infrastructure Support grants; and a Victorian Endowment for Science, Knowledge, and Innovation (VESKI) Fellowship (to R.A.D.).