Structure-Guided Rescaffolding of Selective Antagonists of BCL-X-L

Michael FT Koehler; Philippe Bergeron; Edna F Choo; Kevin Lau; Chudi Ndubaku; Danette Dudley; Paul Gibbons; Brad E Sleebs; Carl S Rye; George Nikolakopoulos; Chinh Bui; Sanji Kulasegaram; Wilhelmus JA Kersten; Brian J Smith; Peter E Czabotar; Peter M Colman; David CS Huang; Jonathan B Baell; Keith G Watson; Lisa Hasvold; Zhi-Fu Tao; Le Wang; Andrew J Souers; Steven W Elmore; John A Flygare; Wayne J Fairbrother; Guillaume Lessene

Journal article

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X-L

Michael FT Koehler, Philippe Bergeron, Edna F Choo, Kevin Lau, Chudi Ndubaku, Danette Dudley, Paul Gibbons, Brad E Sleebs, Carl S Rye, George Nikolakopoulos, Chinh Bui, Sanji Kulasegaram, Wilhelmus JA Kersten, Brian J Smith, Peter E Czabotar, Peter M Colman, David CS Huang, Jonathan B Baell, Keith G Watson, Lisa Hasvold Show all

ACS Medicinal Chemistry Letters | AMER CHEMICAL SOC | Published : 2014

DOI: 10.1021/ml500030p

University of Melbourne Researchers

Peter Czabotar Author Medical Biology (W.E.H.I.)

Guillaume Lessene Author Medical Biology (W.E.H.I.)

David Huang Author Medical Biology (W.E.H.I.)

Peter Colman Author Medical Biology (W.E.H.I.)

Brad Sleebs Author Veterinary Biosciences

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Leukemia and Lymphoma Society

Awarded by Cancer Council of Victoria

Awarded by NHMRC Independent Research Institutes Infrastructure Support Scheme

Funding Acknowledgements

Part of this work was supported by fellowships and grants from the Australian Research Council (fellowship to P.E.C.), the National Health and Medical Research Council (NHMRC, fellowships to J.M.A., J.B.B., P.M.C., and D.C.S.H.; development grant 305536 and program grants 257502, 461221, and 1016701), the Leukemia and Lymphoma Society (specialized center of research grant nos. 7015 and 7413), the Cancer Council of Victoria (fellowship to P.M.C.; grant-in-aid 461239), and the Australian Cancer Research Foundation. Infrastructure support from the NHMRC Independent Research Institutes Infrastructure Support Scheme grant no. 361646 and a Victorian State Government OIS grant are gratefully acknowledged.