Journal article
Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer
LL Christensen, A Holm, J Rantala, O Kallioniemi, MH Rasmussen, MS Ostenfeld, F Dagnaes-Hansen, B Øster, T Schepeler, H Tobiasen, K Thorsen, OM Sieber, P Gibbs, P Lamy, TF Hansen, A Jakobsen, EM Riising, K Helin, J Lubinski, R Hagemann-Madsen Show all
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Abstract
MicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed in human cancers. Particular miRNAs function either as tumor suppressors or oncogenes and appear to have diagnostic and prognostic significance. Although numerous miRNAs are dys-regulated in colorectal cancer (CRC) only a small fraction has been characterized functionally. Using high-throughput functional screening and miRNA profiling of clinical samples the present study aims at identifying miRNAs important for the control of cellular growth and/or apoptosis in CRC. The high-throughput functional screening was carried out in six CRC cell lines transfected with a pre-miR library including 319 sy..
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Awarded by Lundbeckfonden
Funding Acknowledgements
This work was supported by the Danish National Advanced Technology Foundation, the John and Birthe Meyer Foundation, the Danish Council for Independent Research (Medical Sciences), the Danish Council for Strategic Research, the Lundbeck Foundation and The European Union's Seventh Framework Program (SYSCOL HEALTH-F5-2010-258236). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.