Journal article
Tracking motor impairments in the progression of Huntington's disease
JD Long, JS Paulsen, K Marder, Y Zhang, JI Kim, JA Mills, S Cross, P Ryan, EA Epping, S Vik, E Chiu, J Preston, A Goh, S Antonopoulos, S Loi, P Chua, A Komiti, L Raymond, J Decolongon, M Fan Show all
Movement Disorders | Published : 2014
DOI: 10.1002/mds.25657
Abstract
The Unified Huntington's Disease Rating Scale is used to characterize motor impairments and establish motor diagnosis. Little is known about the timing of diagnostic confidence level categories and the trajectory of motor impairments during the prodromal phase. Goals of this study were to estimate the timing of categories, model the prodromal trajectory of motor impairments, estimate the rate of motor impairment change by category, and provide required sample size estimates for a test of efficacy in clinical trials. In total, 1010 gene-expanded participants from the Neurobiological Predictors of Huntington's Disease (PREDICT-HD) trial were analyzed. Accelerated failure time models were used ..
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Awarded by National Center for Advancing Translational Sciences
Funding Acknowledgements
This research is supported by the National Institutes of Health (NIH), the National Institute of Neurological Disorders and Stroke (NS040068), the CHDI Foundation, Inc. (A3917), Cognitive and Functional Brain Changes in Preclinical Huntington's Disease (HD) (5R01NS054893), 4D Shape Analysis for Modeling Spatiotemporal Change Trajectories in Huntington's (1U01NS082086), Functional Connectivity in Pre-manifest Huntington's Disease (1U01NS082083), and Basal Ganglia Shape Analysis and Circuitry in Huntington's Disease (1U01NS082085). The publication was supported by the National Center for Advancing Translational Sciences and the NIH through grant 2 UL1 TR000442-06. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.