Association between index-to-ring finger length ratio and risk of severe knee and hip osteoarthritis requiring total joint replacement

SM Hussain; Y Wang; DC Muller; AE Wluka; GG Giles; JT Manning; S Graves; FM Cicuttini

Journal article

Association between index-to-ring finger length ratio and risk of severe knee and hip osteoarthritis requiring total joint replacement

SM Hussain, Y Wang, DC Muller, AE Wluka, GG Giles, JT Manning, S Graves, FM Cicuttini

Rheumatology United Kingdom | OXFORD UNIV PRESS | Published : 2014

DOI: 10.1093/rheumatology/keu021

Abstract

Objective: The data are conflicting for the association between the index-to-ring finger length ratio (2D:4D) and the risk of OA. The aim of this cohort study was to examine the relationship between 2D:4D and the risk of severe knee and hip OA requiring total joint replacement. Methods: A total of 14 511 participants in the Melbourne Collaborative Cohort Study had 2D:4D assessed from hand photocopies. The incidence of total knee replacement and total hip replacement between 2001 and 2011 was determined by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Results: Over an average 10.5 years of follow-up, 580 participants had total knee r..

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University of Melbourne Researchers

Graham Giles Author

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Funding Acknowledgements

The MCCS was made possible by the contributions of many people, including the original investigators and the diligent team who recruited the participants and who continue working on follow-up. We would like to express our gratitude to the many Melbourne residents who continue to participate in the study. We would like to acknowledge the work of Juliet Anderson, Lily Laskaris and Judith Heads, who measured the vast majority of the digits. For the data linkage, we would especially like to thank registry coordinator Ann Tomkins and statistician Lisa Miller from the Australian Orthopaedic Association National Joint Replacement Registry and Georgina Marr from Cancer Council Victoria. Recruitment for the MCCS was funded by VicHealth and Cancer Council Victoria. This study was funded by a program grant from the National Health Medical Research Council (NHMRC; 209057), a capacity building grant (251533) and an enabling grant (396414), and was further supported by infrastructure provided by Cancer Council Victoria.