Journal article
Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults
RF Buckley, MM Saling, M Irish, D Ames, CC Rowe, VL Villemagne, NT Lautenschlager, P Maruff, SL Macaulay, RN Martins, C Szoeke, CL Masters, SR Rainey-Smith, A Rembach, G Savage, KA Ellis
International Psychogeriatrics | Published : 2014
Abstract
Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal sema..
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Funding Acknowledgements
The AIBL study (www.AIBL.csiro.au) received support from Commonwealth Scientific and Industrial Research Organisation, CSIRO, the Science and Industry Endowment Fund (www.SIEF.org.au), National Health and Medical Research Council, NHMRC, and Dementia Collaborative Research Centres (DCRC), as well as Industry, including Pfizer, Merck, Janssen, and GE Healthcare. We thank all the participants who took part in the study and the clinicians who referred MCI participants to the study.