Journal article

Combination gefitinib and methotrexate treatment for non-tubal ectopic pregnancies: a case series

AW Horne, MM Skubisz, S Tong, WC Duncan, P Neil, EM Wallace, TG Johns



Non-tubal ectopic pregnancies are a rare subgroup of ectopic pregnancies implanted at sites other than the Fallopian tube. Mortality from non-tubal ectopic pregnancies is higher compared with that for tubal ectopic pregnancies, and they are becoming more common, partly due to the rising incidence of Caesarean sections and use of assisted reproductive technologies. Non-tubal ectopic pregnancies can be especially difficult to treat. Surgical treatment is complex, and follow-up after medical treatment is usually protracted. There is therefore a need for more effective medical therapies to resolve non-tubal ectopic pregnancies and reduce operative intervention. We have recently reported successf..

View full abstract


Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC Career Development Fellowship

Awarded by MRC Centenary Award

Awarded by Medical Research Council

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia (NHMRC) Project Grants #606611 (S. T. and T.G.J.), # 1008276 (S. T., E. M. W. and T.G.J.); NHMRC Career Development Fellowship # 1050765 (S. T.); The Monash Institute of Medical Research Flagship Grant (S. T., T.G.J., E. M. W.), The Helen MacPherson Trust (ST), The Victorian Government's Operational Infrastructure Support Program (T.G.J., E. M. W.) and an MRC Clinician Scientist Fellowship and MRC Centenary Award (G0802808, A.W.H.). Funding to pay the Open Access publication charges for this article was provided by the University of Edinburgh.