Journal article
Relationship between sunlight and the age of onset of bipolar disorder: An international multisite study
M Bauer, T Glenn, M Alda, OA Andreassen, E Angelopoulos, R Ardau, C Baethge, R Bauer, F Bellivier, RH Belmaker, M Berk, TD Bjella, L Bossini, Y Bersudsky, EYW Cheung, J Conell, MD Zompo, S Dodd, B Etain, A Fagiolini Show all
Journal of Affective Disorders | Published : 2014
Abstract
Background The onset of bipolar disorder is influenced by the interaction of genetic and environmental factors. We previously found that a large increase in sunlight in springtime was associated with a lower age of onset. This study extends this analysis with more collection sites at diverse locations, and includes family history and polarity of first episode. Methods Data from 4037 patients with bipolar I disorder were collected at 36 collection sites in 23 countries at latitudes spanning 3.2 north (N) to 63.4 N and 38.2 south (S) of the equator. The age of onset of the first episode, onset location, family history of mood disorders, and polarity of first episode were obtained retrospective..
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Awarded by Canadian Institutes of Health Research
Funding Acknowledgements
This work was funded in part by the Canadian Institutes of Health Research (MA, Grant number 64410); the Research Council of Norway (OAA Grant numbers 213837; 223273; 217776); South-East Norway Health Authority (OAA, Grant number 2013-123); a NHMRC Senior Principal Research Fellowship (M Berk, Grant number 1059660; INSERM (BE;Grant number C0829) and APHP (BE, Grant number AOR11096); the Spanish Government (AGP, Grant numbers PS09/02002 CIBER Network; EC10-333, PI10/01430, PI10/01746, PI11/01977, PI11/02708, 2011/1064, 11-BI-01, 1677-DJ-030, EC10-220); European Regional Development Funds (Grant numbers UE/2012/FI-STAR, UE/2013/TENDERMH, UE/2013/MASTERMIND), grants from Spanish Government (Grant numbers PI10/01430, PI10/01746, EC10-220, EC10-333, PI11/01977, 20111064, PI11/02708, PI12/02077, PI13/02252, PI13/00451), local grants from the Basque Government (Grant numbers 200911147, 2010111170, 2010112009, 2011111110, 2011111113); the Basque Foundation for Health Innovation and Research (Grant number BIO12/AL/002); the Spanish Clinical Research Network (Grant numbers CAIBER;1392-D-079) and the University of the Basque Country (Grant number IT679-13); Stanley Research Foundation (Grant number 03-RC-003); the Research Council of Norway (IM, Grant numbers ES488722, ES421716); the Regional Health Authority of South Eastern Norway (IM, Grants number 2011085, 2013088); DFG (AR, Grant numbers SFB TRR 58, B06, Z02); the DFG and Lander funds (AR, Grant number RTG1252/2); Medical Research Council of South Africa (DJS); Spanish Ministry of Economy and Competitiveness (EV, Grants number PI12/00912, PN 2008-2011); the Instituto de Salud Carlos III-Subdireccion General de Evaluacion y Fomento de la Investigacion (EV); Fondo Europeo de Desarrollo Regional Union Europea. Una manera de hacer Europa (EV); CIBERSAM (By); the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (EV, Grant number 2009 SGR 1022). MB, EA, RA, CB, FB, RB, RHB, TDB, LB, YB, EYWC, MDZ, SD, AF, MAF, KNF, JGF, TG, HH, SH, CH, AI, ETI, FK, SK, BK, RK, MK, BL, ERL, CLJ, UL, GM, MM, WM, SM, RM, FGN, CO, YO, AP, DQ, RR, NR, PR, JKR, KS, AMS, ES, CS, SS, AHS, KS, HT, YT, CT, BV, MJW, MZ and PCW have no specific funding to acknowledge. The funding sources had no involvement in the study design, collection, analysis and interpretation of data, in writing the report, and in the decision to submit for publication.