Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity
Sandra Galic, Nirupa Sachithanandan, Thomas W Kay, Gregory R Steinberg
Biochemical Journal | PORTLAND PRESS LTD | Published : 2014
Overactivation of immune pathways in obesity is an important cause of insulin resistance and thus new approaches aimed to limit inflammation or its consequences may be effective for treating Type 2 diabetes. The SOCS (suppressors of cytokine signalling) are a family of proteins that play an essential role in mediating inflammatory responses in both immune cells and metabolic organs such as the liver, adipose tissue and skeletal muscle. In the present review we discuss the role of SOCS1 and SOCS3 in controlling immune cells such as macrophages and T-cells and the impact this can have on systemic inflammation and insulin resistance. We also dissect the mechanisms by which SOCS (1-7) regulate i..View full abstract
Research grants from the National Health and Medical Research Council of Australia and the Canadian Institutes of Health Research support research on SOCS proteins in the laboratories of T.W.K. and G.R.S respectively. G.R.S. is a Canada Research Chair in Metabolism and Obesity.