Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics
Ankit Gupta, Priyanka Shah, Afreen Haider, Kirti Gupta, Mohammad Imran Siddiqi, Stuart A Ralph, Saman Habib
OPEN BIOLOGY | ROYAL SOC | Published : 2014
Apicomplexan protists such as Plasmodium and Toxoplasma contain a mitochondrion and a relic plastid (apicoplast) that are sites of protein translation. Although there is emerging interest in the partitioning and function of translation factors that participate in apicoplast and mitochondrial peptide synthesis, the composition of organellar ribosomes remains to be elucidated. We carried out an analysis of the complement of core ribosomal protein subunits that are encoded by either the parasite organellar or nuclear genomes, accompanied by a survey of ribosome assembly factors for the apicoplast and mitochondrion. A cross-species comparison with other apicomplexan, algal and diatom species rev..View full abstract
Awarded by CSIR's Network project Splendid
A.G., P. S. and K. G. received scholarships from the Council for Scientific and Industrial Research, Government of India and A. H. received scholarship from the University Grants Commission, India. This work was supported by the CSIR's Network project Splendid (BSC0104i) to S. H., and by an Australian National Health and Medical Research Council (NHMRC) project grant to S. A. R. S. A. R. is supported by an NHMRC fellowship. This is CDRI communication no. 8670.