Journal article

Impact of daily high-dose caffeine exposure on developing white matter of the immature ovine brain

Anzari Atik, Jeanie Cheong, Richard Harding, Sandra Rees, Robert De Matteo, Mary Tolocs

PEDIATRIC RESEARCH | NATURE PUBLISHING GROUP | Published : 2014

Abstract

BACKGROUND: Caffeine is widely used to treat apnea of prematurity, but the standard dosing regimen is not always sufficient to prevent apnea. Before higher doses of caffeine can be used, their effects on the immature brain need to be carefully evaluated. Our aim was to determine the impact of daily high-dose caffeine administration on the developing white matter of the immature ovine brain. METHODS: High-dose caffeine (25 mg/kg caffeine base loading dose; 20 mg/kg daily maintenance dose; n = 9) or saline (n = 8) were administered to pregnant sheep from 0.7 to 0.8 of term, equivalent to approximately 27-34 wk in humans. At 0.8 of term, the white and gray matter were assessed histologically an..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Early Career Fellowship


Funding Acknowledgements

This work was funded by the National Health and Medical Research Council of Australia (ID 628312 to M.T., J.C., R.D., S.R., and R.H.), Early Career Fellowship (ID 1053787 to J.C.), and the Victorian Government's Operational Infrastructure Support Program (Government of Victoria).