Journal article
Independent lineages of highly sulfadoxine-resistant Plasmodium falciparum haplotypes, Eastern Africa
SM Taylor, AL Antonia, WE Harrington, MM Goheen, V Mwapasa, E Chaluluka, M Fried, E Kabyemela, M Madanitsa, C Khairallah, L Kalilani-Phiri, AK Tshefu, SJ Rogerson, FO ter Kuile, PE Duffy, SR Meshnick
Emerging Infectious Diseases | CENTERS DISEASE CONTROL | Published : 2014
Open access
Abstract
Sulfadoxine-resistant Plasmodium falciparum undermines malaria prevention with sulfadoxine/pyrimethamine. Parasites with a highly resistant mutant dihydropteroate synthase (dhps) haplotype have recently emerged in eastern Africa; they negated preventive benefits of sulfadoxine/ pyrimethamine, and might exacerbate placental malaria. We explored emerging lineages of dhps mutant haplotypes in Malawi, the Democratic Republic of the Congo, and Tanzania by using analyses of genetic microsatellites flanking the dhps locus. In Malawi, a triple-mutant dhps SGEG (mutant amino acids are underlined) haplotype emerged in 2010 that was closely related to pre-existing double-mutant SGEA haplotypes, suggest..
View full abstractGrants
Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Acknowledgements
M.F. and P.E.D. were supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Instituted of Health.