Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy
Christopher FA Benjamin, Michael M Saling, Amanda G Wood, David C Reutens
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2014
The mesial temporal lobe (MTL) is typically understood as a memory structure in clinical settings, with the sine qua non of MTL damage in epilepsy being memory impairment. Recent models, however, understand memory as one of a number of higher cognitive functions that recruit the MTL through their reliance on more fundamental processes, such as "self-projection" or "association formation". We examined how damage to the left MTL influences these fundamental processes through the encoding of elemental spatial and temporal associations. We used a novel fMRI task to image the encoding of simple visual stimuli, either rich or impoverished, in spatial or spatial plus temporal information. Participa..View full abstract
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Awarded by NH&MRC Program Grant
This research was supported by NH&MRC Program Grant 400121 and in part by a National Academy of Neuropsychology Clinical Research Grant (PI: Benjamin). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.