Journal article

Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy

Christopher FA Benjamin, Michael M Saling, Amanda G Wood, David C Reutens

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2014

Abstract

The mesial temporal lobe (MTL) is typically understood as a memory structure in clinical settings, with the sine qua non of MTL damage in epilepsy being memory impairment. Recent models, however, understand memory as one of a number of higher cognitive functions that recruit the MTL through their reliance on more fundamental processes, such as "self-projection" or "association formation". We examined how damage to the left MTL influences these fundamental processes through the encoding of elemental spatial and temporal associations. We used a novel fMRI task to image the encoding of simple visual stimuli, either rich or impoverished, in spatial or spatial plus temporal information. Participa..

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