Journal article
Decreased serum zinc is an effect of ageing and not Alzheimer's disease
A Rembach, DJ Hare, JD Doecke, SC Burnham, I Volitakis, CJ Fowler, RA Cherny, C McLean, R Grimm, R Martins, D Ames, CL Masters, AI Bush, BR Roberts
Metallomics | ROYAL SOC CHEMISTRY | Published : 2014
DOI: 10.1039/c4mt00060a
Abstract
We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed. © 2014 the Partner Organisations.
Grants
Funding Acknowledgements
We wish to thank the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (http://www.aibl.csiro.au/), including all scientists, participants and their families. This work was supported by the Cooperative Research Centre for Mental Health and by Operational Infrastructure Support from the Victorian State Government.