Journal article
Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ
KL Good-Jacobson, Y Chen, AK Voss, GK Smyth, T Thomas, D Tarlinton
Proceedings of the National Academy of Sciences of the United States of America | Published : 2014
Abstract
Memory B cells and long-lived bone marrow-resident plasma cells maintain humoral immunity. Little is known about the intrinsic mechanisms that are essential for forming memory B cells or endowing them with the ability to rapidly differentiate upon reexposure while maintaining the population over time. Histone modifications have been shown to regulate lymphocyte development, but their role in regulating differentiation and maintenance of B-cell subsets during an immune response is unclear. Using stage-specific deletion of monocytic leukemia zinc finger protein (MOZ), a histone acetyltransferase, we demonstrate that mutation of this chromatin modifier alters fate decisions in both primary and ..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC) Australia
Funding Acknowledgements
We thank Ingela Vikstrom and Dimitra Zotos for critical reading of this manuscript, Simon Willis for helpful discussions, and Dana Piovesan and D. T. laboratory members for technical assistance. This work is supported by a National Health and Medical Research Council (NHMRC) Australia Program Grant (to D. T.; 1054925) and Project Grant (to K.L.G.-J.; 1022458). K.L.G.-J. is supported by an NHMRC Biomedical Research Fellowship, and A. K. V., G. K. S., T. T., and D. T. by NHMRC Research Fellowships. This work was made possible through the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme.