Journal article
Juvenile polymyositis or paediatric muscular dystrophy: A detailed re-analysis of 13 cases
CE D'Arcy, MM Ryan, CA McLean
Histopathology | WILEY | Published : 2009
Abstract
Aims: There has been much debate about the existence of juvenile polymyositis (JPM) as an entity distinct from muscular dystrophy (MD). The aim of this study was to retrospectively analyse muscle biopsies and clinical features of 13 Australian children given an initial diagnosis of JPM, to determine their clinicopathological, immunohistochemical and molecular characteristics. Methods and results: The muscle biopsies on 13 cases were reviewed using detailed morphological and immunoperoxidase studies, with additional protein and molecular analyses, in conjunction with clinical review. Only one case had a true connective tissue disease inflammatory myopathy. Twelve (92.3%) cases with an initial..
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Funding Acknowledgements
The authors thank Paul Kennedy and Veronika Gazdik from the State Neuropathology Service; Laura Leone and Tiffany Cowie from the Department of Pathology, University of Melbourne; and Vicki Schiavon, from the Department of Anatomical Pathology Laboratory, The Alfred, for assistance with investigative laboratory work. This study was also supported by a Medical School Scholarship from the Royal College of Pathologists, Australasia.