Water drinking and the effect of angiotensin and renin in a dasyurid marsupial (Antechinus stuartii)

Abstract

Marsupial mice, Antechinus stuartii, were given intraperitoneal (ip) injections of 1-30 μg of Val5-angiotensin II amide to determine whether it had any effect on thirst. Drinking in the first hour after injection and measured water intake over 2 and 24 hr were not substantially increased compared with controls. Intraperitoneal injection of sheep renin had no effect on water intake. Water deprivation increased 2- and 24-hr water intake. Sheep renin and Val5-angiotensin II amide elicited pressor responses after ip injection. By comparison, rats given 100 μg of Val5-angiotensin II amide ip increased water intake in the first 2 hr after injection compared with saline-injected and noninjected con..