Antibody and Cell Mediated Immune Responses to an Inactivated Feline Panleukopenia Virus Vaccine

Abstract

Serum haemagglutination inhibiting and plaque reduction neutralizing antibodies were detected in cats given 2 doses of an adjuvanted inactivated feline panleukopenia virus vaccine. Plaque reduction neutralizing antibody titres were approximately 3 to 1126‐fold higher than haemagglutination inhibiting antibody titres. Suppression of in vitro concanavalin A‐induced lymphocyte blastogenesis was observed following vaccination; the stimulation indices of both whole and washed blood cultures were approximately equally suppressed on day 3 to day 24 or 28. In vitro feline panleukopenia virus antigen‐induced lymphocyte blastogenesis with stimulation indices > 2 were detected as early as day 3 followi..