Journal article

Neurotrophin-3, but not nerve growth factor, promotes survival of human intestinal mast cells

A Lorentz, J Hoppe, H Worthmann, T Gebhardt, U Hesse, J Bienenstock, SC Bischoff

Neurogastroenterology & Motility | BLACKWELL PUBLISHING | Published : 2007

Abstract

Neurotrophins are potent regulators of neuronal cell survival and function. Nerve growth factor (NGF) was shown to reduce apoptosis in cord blood-derived mast cells. Here, we examined the effect of the neurotrophins NGF and neurotrophin (NT)-3 on survival and mediator release of human intestinal mast cells. Mast cells isolated from normal intestinal tissue were cultured in the presence of NGF, NT-3, or stem cell factor (SCF) alone or in the presence of SCF together with each neurotrophin. NGF or NT-3 alone did not promote mast cell survival. In contrast, mast cell recovery was increased twofold when mast cells were cultured with NT-3 in addition to SCF for 14 days compared with control. Mast..

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University of Melbourne Researchers