Journal article

Sleep deprivation increases cortical excitability in epilepsy - Syndrome-specific effects

RAB Badawy, JM Curatolo, M Newton, SF Berkovic, RAL Macdonell

NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

Abstract

OBJECTIVE: To use transcranial magnetic stimulation (TMS) to investigate the hypothesis that sleep deprivation increases cortical excitability in people with epilepsy. METHODS: We performed paired pulse TMS stimulation, using a number of interstimulus intervals (ISIs) on each hemisphere of 30 patients with untreated newly diagnosed epilepsy (15 idiopathic generalized epilepsy [IGE] and 15 focal epilepsy) and on the dominant hemisphere of 13 healthy control subjects, before and after sleep deprivation. RESULTS: Both hemispheres in patients with IGE and the hemisphere ipsilateral to the EEG seizure focus in those with focal epilepsy showed an increase in cortical excitability following sleep d..

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