Olfactory Deficits and Amyloid-beta Burden in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Aging: A PiB PET Study
Alex Bahar-Fuchs, Gael Chetelat, Victor L Villemagne, Simon Moss, Kerryn Pike, Colin L Masters, Christopher Rowe, Greg Savage
Journal of Alzheimer's Disease | IOS PRESS | Published : 2010
Olfactory deficits and increased amyloid-β (Aβ) burden are observed in people with amnestic mild cognitive impairment (aMCI); both factors may be predictive of Alzheimer's disease (AD). We explored whether olfactory identification is related to in vivo measures of Aβ burden using Pittsburgh Compound B (PiB) PET. Nineteen control, 24 aMCI, and 20 AD participants completed an olfactory identification task and underwent PiB PET scanning. Control participants performed better on olfactory identification and showed lower PiB binding than aMCI patients. There was a significant correlation between both factors when pooling all groups together but not when considering each group separately. In addit..View full abstract
Unrestricted educational research grants were provided from Neurosciences Victoria, Austin Hospital Medical Research Foundation, and the Commonwealth Government of Australia Department of Health and Ageing.