Journal article

Dumb and dumber - The potential waste of a useful antistaphylococcal agent: Emerging fusidic acid resistance in Staphylococcus aureus

BP Howden, ML Grayson

CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2006

Abstract

Fusidic acid has activity against a range of pathogens but has mainly been used to treat staphylococcal infections. Fusidic acid monotherapy, especially topical preparations, has been strongly associated with the emergence of fusidic acid resistance among both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus. Key resistance determinants include mutations in the fusA gene, which encodes elongation factor G, and plasmid-mediated resistance (i.e., acquisition of resistance gene fusB). Clonal outbreaks of fusidic acid-resistant S. aureus have been noted throughout the United Kingdom and Europe, such that the efficacy of fusidic acid is threatened. Fusidic ..

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University of Melbourne Researchers