Journal article

Vascular effects of PTHrP (1-34) and PTH (1-34) in the human fetal-placental circulation

K Macgill, JM Moseley, TJ Martin, SP Brennecke, GE Rice, ME Wlodek

PLACENTA | W B SAUNDERS CO LTD | Published : 1997

Abstract

The aim of this study was to examine the vasodilatory effects of parathyroid hormone-related protein (PTHrP) (1-34) and parathyroid hormone (PTH) (1-34) on the human fetal-placental circulation utilising an in vitro placental perfusion model. In all experiments, the vasculature of an isolated human placental cotyledon was pre-constricted with the thromboxane A2 mimetic U46619. A simple dose of PTHrP (1-34) or PTH (1-34) (1.7-300 nM) was then infused into the fetal-placental circulation of the cotyledon. In other experiments, cotyledons were repeatedly infused with PTHrP (1-34) or PTH (1-34) (51.3 nM). Vasodilatory responses were significantly reduced in response to repeated exposure to PTHrP..

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