Journal article

NEUROCHEMICAL STUDIES OF THE MESOLIMBIC DOPAMINERGIC PATHWAY - GLYCINERGIC MECHANISMS AND GLYCINERGIC-DOPAMINERGIC INTERACTIONS IN THE RAT VENTRAL TEGMENTUM

AL GUNDLACH, PM BEART

JOURNAL OF NEUROCHEMISTRY | WILEY-BLACKWELL | Published : 1982

Abstract

The rat ventral tegmentum (containing somata and dendrites of mesolimbic dopaminergic neurones) contained 1.3 mumol/g wet weight of glycine. Slices of ventral tegmentum accumulated exogenous [3H]glycine by an energy-, temperature- and sodium-dependent mechanism. The uptake was medicated by two different transport systems; one system with relatively low affinity for glycine (Km approximately 400 microM) and the other a higher affinity for glycine (Km approximately 10 microM). Small amino acid analogues of glycine inhibited the uptake process, the most potent being taurine and beta-alanine (47% and 44% inhibition, respectively, at 1 mM). Release of exogenous [3H]glycine by elevated potassium a..

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