Journal article

OPIOID PEPTIDE GENE-EXPRESSION IN THE NUCLEUS-TRACTUS-SOLITARIUS OF RAT-BRAIN AND INCREASES INDUCED BY UNILATERAL CERVICAL VAGOTOMY - IMPLICATIONS FOR ROLE OF OPIOID NEURONS IN RESPIRATORY CONTROL MECHANISMS

SD RUTHERFURD, AL GUNDLACH

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 1993

Abstract

Neurons expressing messenger RNA encoding the opioid peptide precursors, preproenkephalin and preprodynorphin were localized in the medulla oblongata of the rat by in situ hybridization of specific DNA oligonucleotide probes. Neurons containing preproenkephalin messenger RNA were found throughout the medullary reticular formation in the gigantocellular and paragigantocellular reticular nuclei, the parvicellular and lateral reticular nuclei; commissural, medial and ventrolateral subnuclei in the nucleus tractus solitarius and the nucleus of the spinal trigeminal tract. Labelled cells were also concentrated in the more medial regions of the area postrema. In contrast, neurons containing prepro..

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University of Melbourne Researchers