Conference Proceedings

Distribution, regulation and role of hypothalamic galanin systems: Renewed interest in a pleiotropic peptide family

AL Gundlach, TCD Burazin, JA Larm

Clinical and Experimental Pharmacology and Physiology | BLACKWELL SCIENCE ASIA | Published : 2001


1. Galanin peptide and galanin receptor-binding sites are known to be widely distributed within the central nervous system, particularly in the hypothalamus in the preoptic area, the paraventricular (PVN) and supraoptic (SON) nuclei and the arcuate nucleus/median eminence. 2. The present brief review focuses on some recent studies of the regional and cellular localization of mRNA encoding galanin and two galanin receptor subtypes (GalR1 and GalR2) in the hypothalamus, regulation of galanin and/or galanin receptor expression in various nuclei by physiological stimuli, electrophysiological effects of galanin on hypothalamic neurons and the isolation and cloning of galanin-like peptide (GALP), ..

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