Journal article

The quest for Eldorado: Development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain

Andrew G Horti, Victor L Villemagne

Current Pharmaceutical Design | BENTHAM SCIENCE PUBL LTD | Published : 2006


Neuronal nicotinic acetylcholine receptors (nAChRs), ubiquitously distributed in the human brain, are implicated in various neurophysiological processes and in the pathophysiology and/or treatment strategies of Alzheimer's and Parkinson's diseases, Tourette's syndrome, epilepsy, schizophrenia, depression, and anxiety, as well as being particularly affected in tobacco dependence/withdrawal. In the past two decades, researchers have developed an extensive series of radioligands for the assessment of nAChRs in vivo through emission tomography, PET and SPECT. Several radioligands, derivatives of A-85380: 2-[(18)F]FA, 6-[(18)F]FA and 5-[(123)I]IA, are now being employed for the evaluation of nACh..

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University of Melbourne Researchers