Journal article

Rotavirus vaccines in developed countries

Jim P Buttery, Carl Kirkwood

Current Opinion in Infectious Diseases | LIPPINCOTT WILLIAMS & WILKINS | Published : 2007


PURPOSE OF REVIEW: Rotavirus is the most common cause of diarrhoea and dehydration in early childhood. The recent licensure in many nations of vaccines against rotavirus offers promise to significantly reduce this toll. The present review describes recent developments regarding rotavirus vaccines and the challenges they face. RECENT FINDINGS: Rotavirus causes significant morbidity and impact upon healthcare systems, at both inpatient and outpatient levels. An earlier rotavirus vaccine, since withdrawn, was temporally associated with intussusception causing small bowel obstruction, especially in infants receiving their first dose at an older age. Large-scale safety and efficacy studies of two..

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