Case-Control Evaluation of the Effectiveness of the G1P Human Rotavirus Vaccine during an Outbreak of Rotavirus G2P Infection in Central Australia
TL Snelling, RM Andrews, CD Kirkwood, S Culvenor, JR Carapetis
Clinical Infectious Diseases | UNIV CHICAGO PRESS | Published : 2011
UNLABELLED: The human rotavirus vaccine was evaluated during an outbreak of rotavirus G2P infection in central Australia. No overall protective effect against hospitalization was demonstrated, raising concerns over the durability of vaccine protection against heterotypic strains. BACKGROUND: Two and a half years after commencing routine vaccination with human rotavirus vaccine, an outbreak of rotavirus G2P infection occurred in central Australia. Vaccine effectiveness against a P-containing strain (G9P) had been demonstrated previously in this setting. This subsequent outbreak provided the opportunity to evaluate vaccine effectiveness against hospitalizations for a non-vaccine-re..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
This study was funded by a National Health and Medical Research Council (NHMRC; 545233) and GlaxoSmithKline, the manufacturer of Rotarix. TLS is supported by a NHMRC Primary Health Care Scholarship, and CDK is supported by a NHMRC Career Development Award Fellowship.