Journal article

Case-Control Evaluation of the Effectiveness of the G1P[8] Human Rotavirus Vaccine during an Outbreak of Rotavirus G2P[4] Infection in Central Australia

TL Snelling, RM Andrews, CD Kirkwood, S Culvenor, JR Carapetis

Clinical Infectious Diseases | UNIV CHICAGO PRESS | Published : 2011

Abstract

UNLABELLED: The human rotavirus vaccine was evaluated during an outbreak of rotavirus G2P[4] infection in central Australia. No overall protective effect against hospitalization was demonstrated, raising concerns over the durability of vaccine protection against heterotypic strains. BACKGROUND: Two and a half years after commencing routine vaccination with human rotavirus vaccine, an outbreak of rotavirus G2P[4] infection occurred in central Australia. Vaccine effectiveness against a P[8]-containing strain (G9P[8]) had been demonstrated previously in this setting. This subsequent outbreak provided the opportunity to evaluate vaccine effectiveness against hospitalizations for a non-vaccine-re..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This study was funded by a National Health and Medical Research Council (NHMRC; 545233) and GlaxoSmithKline, the manufacturer of Rotarix. TLS is supported by a NHMRC Primary Health Care Scholarship, and CDK is supported by a NHMRC Career Development Award Fellowship.