Journal article

Awareness in children: a secondary analysis of five cohort studies

AJ Davidson, KR Smith, HJ Blusse van Oud-Alblas, U Lopez, S Malviya, CF Bannister, JL Galinkin, W Habre, C Ironfield, T Voepel-Lewis, F Weber

Anaesthesia | WILEY-BLACKWELL | Published : 2011

Abstract

Five recent cohort studies have shown a frequency of awareness in paediatric anaesthesia of between 0.2% and 1.2%, but they were not individually large enough to identify risk factors. This study pooled raw data from these five studies to identify factors associated with awareness in children. The outcome of awareness was taken as the cases judged to be most likely awareness cases in each study. Logistic regression was used to identify awareness-associated factors. A combined sample of 4486 anaesthetics revealed 33 cases of awareness. Unadjusted analysis demonstrated weak evidence that nitrous oxide used as an anaesthetic maintenance adjunct was associated with awareness (OR 2.04 (95% CI 0.9..

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