Journal article

Oxidative processes in Alzheimer's disease: the role of A beta-metal interactions

T Lynch, RA Cherny, AI Bush

Experimental Gerontology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2000

Abstract

Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex and the concomitant deposition of Amyloid beta (Abeta). Abeta is a metalloprotein that binds copper, and is electrochemically active. Abeta converts molecular oxygen into hydrogen peroxide by reducing copper or iron, and this may lead to Fenton chemistry. Hydrogen peroxide is a freely permeable prooxidant that may be responsible for many of the oxidative adducts that form in the Alzheimer-affected brain. The electrochemical activity of various Abeta species correlates with the peptides' neurotoxicity in cell culture, and participation in the neuropathology of Alzheimer's disease. These reactions presen..

View full abstract