INFLUENCE OF ROUTE OF ADMINISTRATION ON PROGESTERONE METABOLISM
B DELIGNIERES, L DENNERSTEIN, T BACKSTROM
Maturitas | ELSEVIER IRELAND LTD | Published : 1995
While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.