Does hippocampal atrophy on MRI predict cognitive decline? A prospective follow-up study

Abstract

Objectives. To investigate whether the presence of hippocampal atrophy (HCA) on MRI in Alzheimer's disease (AD) leads to a more rapid decline in cognitive function. To investigate whether cognitively unimpaired controls and depressed subjects with HCA are at higher risk than those without HCA of developing dementia. Design. A prospective follow-up of subjects from a previously reported MRI study. Setting. Melbourne, Australia. Participants. Five controls with HCA and five age-matched controls without HCA, seven depressed subjects with HCA and seven without HCA, and 12 subjects with clinically diagnosed probable AD with HCA and 12 without HCA were studied. They were followed up at approximate..