Journal article

Failure to vaccinate or failure of vaccine? Effectiveness of the 23-valent pneumococcal polysaccharide vaccine program in Indigenous adults in the Northern Territory of Australia

S Moberley, V Krause, H Cook, K Mulholland, J Carapetis, P Torzillo, R Andrews

Vaccine | ELSEVIER SCI LTD | Published : 2010

Abstract

Over the last decade, there has been no discernible reduction in Invasive Pneumococcal Disease (IPD) amongst Indigenous adults in the Northern Territory (NT) of Australia, despite increasing vaccination coverage. We examined the utility of two common methods, the screening method and the indirect method, to determine the 23-valent pneumococcal polysaccharide vaccine effectiveness (VE) in prevention of IPD amongst Indigenous adults in this setting. VE was calculated for the period 2001-2005 across two distinct geographical areas where the disease burden was known to differ. VE against vaccine-type IPD was 3.4% (95% CI -43, 35) for the NT. However, population vaccination coverage varied widely..

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Grants

Awarded by The National Health and Medical Research Council


Funding Acknowledgements

The National Health and Medical Research Council (ID 384490) & Centre for Clinical Research Excellence (Indigenous Immunisation) provided a Postgraduate Public Health Scholarship for Sarah Moberley.