Journal article

Hypothalamic 3 ',5 '-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice

T Mantamadiotis, O Kretz, S Ridder, SC Bleckmann, D Bock, HJ Grone, J Malaterre, S Dworkin, RG Ramsay, G Schutz

Endocrinology | OXFORD UNIV PRESS INC | Published : 2006

Abstract

The principal regulation of body growth is via a cascade of hormone signals emanating from the hypothalamus, by release of GHRH, which then directs the somatotroph cells of the pituitary to release GH into the blood stream. This in turn leads to activation of signal transducer and activator of transcription 5-dependent expression of genes such as IGF-I in hepatocytes, acid labile substance, and serine protease inhibitor 2.1, resulting in body growth. Here, using conditional cAMP response element binding protein (CREB) mutant mice, we show that loss of the CREB transcription factor in the brain, but not the pituitary, results in reduced postnatal growth consistent with dwarfism caused by GH d..

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